The Prešov Region is one of the eight Slovak administrative regions and consists of 13 districts (okresy) and 666 municipalities, 23 of which have town status. The region was established in 1996 and is the most populous of all the regions in Slovakia. Its administrative centre is the city of Prešov.
It is located in the north-eastern Slovakia and has an area of 8,975 km2. The region has a predominantly mountainous landscape. The subdivisions of Tatras – High Tatras and Belianske Tatras lie almost entirely in the region and include the highest point of Slovakia – Gerlachovský štít (2,654 ASL).